What is noninsulin medicines?

There are different types of noninsulin medicines for diabetes. Each works in a different way. But they all help you control your blood sugar. Some types help your body make insulin to lower your blood sugar. Others lower how much insulin your body needs. Some can slow how fast your body digests sugars. And some can remove extra glucose through your urine.

You may need to take more than one medicine for diabetes. Two or more medicines may work better to lower your blood sugar level than just one does.

• Metformin. This lowers how much glucose your liver makes. And it helps you respond better to insulin. It also lowers the amount of stored sugar that your liver releases when you are not eating.
• Sulfonylureas. These help your body release more insulin. Some work for many hours. They can cause low blood sugar if you don't eat as you planned. An example is glipizide.
• Thiazolidinediones. These reduce the amount of blood glucose. They also help you respond better to insulin. An example is pioglitazone.
• SGLT2 inhibitors. These help to remove extra glucose through your urine. They may also help some people lose weight. An example is ertugliflozin.
• DPP-4 inhibitors. These help your body raise the level of insulin after you eat. They also help your body make less of a hormone that raises blood sugar. An example is alogliptin.
• GLP-1 receptor agonists. These help your body make a protein that can raise your insulin level and make you less hungry. They're given as shots or pills. An example is semaglutide.
• Meglitinides. These help your body release insulin. They also help slow how your body digests sugars. So they can keep your blood sugar from rising too fast after you eat.
• Alpha-glucosidase inhibitors. These keep starches from breaking down. This means that they lower the amount of glucose absorbed when you eat. They don't help your body make more insulin. So they will not cause low blood sugar unless you use them with other medicines for diabetes.

Noninsulin medicines for diabetes help you control blood sugar. You take oral medicines by mouth. Some noninsulin medicines are injected into the body with a needle. One of the noninsulin medicines, metformin, is sometimes used to treat prediabetes.

There are different types of noninsulin medicines for diabetes. Each works in a different way. You may need to take more than one medicine. Examples include:

• Metformin. This lowers how much glucose your liver makes and helps your body use insulin.
• Sulfonylureas. These help your body release more insulin. An example is glipizide.
• Thiazolidinediones. These reduce the amount of blood glucose. An example is pioglitazone.
• SGLT2 inhibitors. These help to remove extra glucose through your urine. An example is ertugliflozin.
• DPP-4 inhibitors. These help your body increase insulin after you eat and make less of a hormone that raises blood sugar. An example is alogliptin.
• GLP-1 receptor agonists. These help your body make a protein that can raise your insulin level and make you less hungry. An example is semaglutide.
• Meglitinides. These help your body release insulin. They also help slow how your body digests sugars.

Cautions for noninsulin medicines for diabetes include the following:

• It is important to check your blood sugar as your doctor says. If a medicine is not working well, you may need to try other medicines or combinations.

• Eat a healthy diet. Get some exercise each day. This may help you to reduce how much medicine you need.
• Do not take other prescription or over-the-counter medicines, vitamins, herbal products, or supplements without talking to your doctor first. Some medicines for type 2 diabetes can cause problems with other medicines or supplements.
• Tell your doctor if you plan to get pregnant. Some of these drugs are not safe for pregnant women.
• Be safe with medicines. Take your medicines exactly as prescribed. Meglitinides and sulfonylureas can cause your blood sugar to drop very low. Call your doctor if you think you are having a problem with your medicine.
• Check your blood sugar often. You can use a glucose monitor. Keeping track can help you know how certain foods, activities, and medicines affect your blood sugar. And it can help you keep your blood sugar from getting so low that it's not safe.